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Within the third yr of the pandemic, COVID-19—and particularly long COVID— continued to be a priority for POZ readers (No. 11 and 17). But it surely was overshadowed by a brand new infectious illness that primarily impacted homosexual males: monkeypox, now renamed mpox (No. 4, 9, 12 and 18). Though mpox instances have declined dramatically because the outbreak’s peak in July and August, it stays a menace for folks dwelling with HIV, particularly these with a detectable viral load or a low CD4 cell depend (No. 5 and eight).
Now that antiretroviral therapy and HIV pre-exposure prophylaxis (PrEP) are extremely efficient and broadly used, new therapies should not getting as a lot consideration. However researchers did current findings suggesting that the long-acting therapy Cabenuva (cabotegravir and rilpivirine) might be appropriate for more people and that injectable therapy and PrEP may doubtlessly be self-administered. And simply final week—too late to make it into the annual rating—the Meals and Drug Administration authorised the primary HIV capsid inhibitor, Sunlenca (lenacapavir), as a twice-yearly therapy choice for folks with extremely resistant HIV.
POZ readers additionally took an curiosity in a brand new prevention device: utilizing the antibiotic doxycycline after intercourse to stop sexually transmitted infections, an method dubbed doxyPEP (No. 13).
Lastly, readers proceed to eagerly search HIV treatment information (No. 6 and 16). Whereas final yr’s high tales prominently featured HIV vaccines, this yr’s rating consists of all kinds of experimental approaches, together with checkpoint inhibitors (No. 1), CAR-T remedy (No. 2), mRNA vaccines (No. 14), broadly neutralizing antibodies (No. 10, 15 and 19) and—too late for the rating—CRISPR gene editing to snip HIV out of cells.
Listed here are the POZ science information tales with essentially the most views this yr:
1. Cancer Immunotherapy Flushes HIV Out of Hiding
Posted: February 9
2. Researchers Explore CAR-T Therapy as a Potential Cure for HIV
Posted: November 28
3. A Majority of Transgender Women With HIV Are Undetectable
Posted: January 25
4. Study Reveals Novel Monkeypox Symptoms and Transmission Routes
Posted: July 23
5. A Large Proportion of Men with Monkeypox Are Living With HIV
Posted: August 23
6. People Who Start HIV Treatment With High CD4s Have a Smaller Viral Reservoir
Posted: July 6
7. Widely Used Meds Linked to Falls and Frailty in Older People With HIV
Posted: April 13
8. Monkeypox: What Do People Living With or at Risk for HIV Need to Know?
Posted: June 15
9. Monkeypox Reaches Multiple Countries, Including U.S.
Posted: Might 24
10. Broadly Neutralizing Antibody Leads to Long-Term HIV Remission
Posted: Might 11
11. Long COVID Symptoms Linked to Inflammation
Posted: June 29
12. Monkeypox Is Not Airborne, CDC Says
Posted: June 16
13. Taking Antibiotics After Sex Reduces STI Risk
Posted: August 15
14. HIV mRNA Vaccine Trial Is Now Underway
Posted: January 28
15. Broadly Neutralizing Antibody Shows Promise for Long-Acting HIV Treatment
Posted: November 23
16. Understanding Where HIV Hides Offers Clues for a Cure
Posted: January 17
17. A Majority of People With HIV Have Asymptomatic COVID
Posted: April 20
18. Monkeypox Heavily Impacts Black and Latino Gay Men
Posted: August 18
19. Broadly Neutralizing Antibodies Delay HIV Rebound
Posted: April 27
20. Gay Latino Men at Highest Risk for HIV Are Five Times More Likely to Use PrEP
Posted: March 24
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