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TUESDAY, Dec. 20, 2022 (HealthDay Information) — Positron emission tomography (PET) adjustments are comparable for individuals with autosomal dominant Alzheimer illness and people with Down syndrome, in keeping with a research revealed within the January situation of The Lancet Neurology.
Anna H. Boerwinkle, from the Washington College College of Drugs in St. Louis, and colleagues in contrast amyloid adjustments for individuals with autosomal dominant Alzheimer illness and people with Down syndrome in a cross-sectional research. Information had been included for 192 people with Down syndrome and 33 sibling controls, and 265 carriers of autosomal dominant Alzheimer illness mutations and 169 noncarrier familial controls.
The researchers discovered that in carriers of autosomal dominant Alzheimer illness mutations and in individuals with Down syndrome, PET amyloid centiloid and cerebrospinal fluid Aβ42/40 had been negatively correlated. No distinction was seen in international PET amyloid burden between asymptomatic people with Down syndrome and asymptomatic mutation carriers, or between symptomatic individuals with Down syndrome and symptomatic mutation carriers. In contrast with these with Down syndrome, mutation carriers confirmed elevated amyloid deposition considerably earlier. This distinction was primarily pushed by PSEN1 mutations. For mutation carriers and other people with Down syndrome, early amyloid accumulation occurred in striatal and cortical areas. Widespread amyloid accumulation was seen in all cortical areas in mutation carriers, however in individuals with Down syndrome, the median occipital areas had been spared.
“This research reveals that, though there are refined variations, Alzheimer’s illness pathophysiology is analogous amongst individuals with Down syndrome and other people with autosomal dominant Alzheimer’s illness,” the authors write.
A number of authors disclosed monetary ties to the pharmaceutical trade.
Abstract/Full Text (subscription or payment may be required)
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